Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering





1. Zhiguo Lu,Ruichen Zhao, Yi Li, Jianze Wang,Jing Guo, Chaobo Bai, Jing Chen, Jun Yang, Yiwan Geng, Tianlu Zhang, Yanyue Wu, Xiyue Jiao, Yining Wang*, Junliang Yuan*, Xin Zhang*, Smart antioxidant function enhancing (SAFE) nucleic acid therapy for ROS-related chronic diseases and comorbidities. Bioactive Materials. 2024, 31, 509-524.(IF=18.9)

2. Yanyue Wu, Jun Yang, Yiwan Geng, Xiyue Jiao, Zhiguo Lu, Tianlu Zhang, Ruichen Zhao, Jing Guo, Wenli Wang, Jing Wang*, Xin Zhang*, A BIOMIMIC nanobullet with ameliorative inflammatory microenvironment for Alzheimer's diseases’ treatmentsAdvanced Healthcare Materials2024, 13, 6, 2302851. (IF=10.6)


1. Zhiguo Lu*, Jie Shen, Jun Yang, Jingwen Wang, Ruichen Zhao, Tianlu Zhang, Jing Guo, Xin Zhang*, Nucleic acid drug vectors for diagnosis and treatment of brain diseases. Signal Transduction and Targeted Therapy. 2023, 8, 2, 604-656. (IF 38.12)

2. Jie Shen, Jingwen Wang, Qiulian Hao, Weihong Ji, Huan Peng, Yanyue Wu, Ruichen Zhao, Xinyu Qiu, Wenl Wang, Jun Yang, Yan Li, Tianlu Zhang, Zhiguo Lu*, Xin Zhang*, Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs’                       Spatiotemporal    Behaviors. Advanced Functional Materials. 2023, 33, 5, 2209749. (IF=19.978) 

3. Yanyue Wu, Wenli Wang, Xinyu Qiu, Zhiguo Lu, Weihong Ji, Jie Shen, Huan Peng, Ruichen Zhao, Jingwen Wang, Tianlu Zhang, Jun Yang*,Xin Zhang* A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson's

disease treatments. Nano Research. 2023, 16(5): 7216−7226. (IF=10.269)


1. Huan Peng#,Yan Li#, Weihong Ji, Ruichen Zhao, Zhiguo Lu, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Jingwen Wang, Wenli Wang, Jun Yang,  Xin Zhang*.  Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinsons Disease. ACS Nano, 2022,16,1,869-884. (IF=18.02) 

2. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Xin Zhang*.Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases. Advanced Drug Delivery Reviews, 2022, 180,114029.(IF=21.65) 

3. Ruiyuan Liu#, Jun Yang#, Xinyu Qiu, Weihong Ji, Jie Shen, Yan Li, Zhiguo Lu, Yanyue Wu, Wenli Wang, Jing Wang, Jifu  Hao, Xin Zhang, “Cascaded rocket” nanosystems with spatiotemporal separation for triple-synergistic therapy of     Alzheimer’s diseaseAdvanced Healthcare Materials, 2022, 11: 2101748. 11.092  (IF=11.092) 


1.  Jie Shen, Zhiguo Lu, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 2101993. (IF= 32.09)

2. Weihong Ji, Yan Li, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, ZhiguoLu, JunYang, XinZhang*. Selfcatalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021, 202105711.  (IF= 32.09)

3. Weihong Ji, Yan Li, Ruiyuan Liu, Zhiguo Lu, Linying Liu, Zhuyan Shi, Jie Shen, Xin Zhang*. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a ‘‘nanoguard’’ for synergistic treatment of synucleinopathies. Materials Horizons, 2021, 8, 1199-1206. (IF= 16.15)


1.  Ruiyuan Liu Jun Yang Linying Liu Zhiguo Lu Zhuyan Shi Weihong Ji Jie Shen Xin Zhang* An ‘Amyloid-β  Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial DysfunctionAdvanced Science, 2020, 7, 1901555. (IF= 18.939)

2. Yan Li, Linying Liu, Weihong Ji, Huan Peng, Ruichen Zhao, Xin Zhang*. Strategies and materials of “SMART” non-viral vectors: Overcoming thebarriers for brain gene therapy. Nano Today, 2020, 35: 101006. (IF=20.24)

3. Linying Liu,Yan Li, Huan Peng, Ruiyuan Liu,Weihong Ji, Zhuyan Shi, JieShen,Guanghui Ma, Xin Zhang*.Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease. Science Advances, 2020, 6: eaba3967. (IF=16.9)

4. Jun Yang Zhuyan Shi Ruiyuan Liu Yanyue Wu Xin Zhang* Combined-therapeutic strategies synergistically  potentiate glioblastoma multiforme treatment via nanotechnology Theranostics, 2020, 10(7)3223-3239. (IF=12.201)

5. Zhiguo Lu, Jianze Wang, Lina Qu, Guanghan Kan,Tianlu Zhang, Jie Shen,Yan Li, Jun Yang, Yunwei Niu, Zuobing Xiao,Yinghui Li*, Xin Zhang*. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. Bioact. Mater. 2020, 5 (4), 1127-1137.  (IF=17.363)


 1.  Qi Shen, Jun Yang, Ruiyuan Liu, Linying Liu, Jinchao Zhang, Shigang Shen*, Xin Zhang*. Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy. Materials Horizons. 2019, 6, 810-816. (IF=16.15)

  2.  Linying Liu, Yan Li, Ruiyuan Liu, Qi Shen, Yanhui Li, Zhuyan Shi, Jie Shen, Weihong Ji, Xin Zhang*, Switchable  Nanoparticle for Programmed Gene-chem Delivery with Enhanced Neuronal Recovery and CT Imaging for Neurodegenerative Disease Treatment. Materials Horizons, 2019, 6, 1923-1929.  (IF=16.15)


1.   Chenmeng Qiao, Jun Yang, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*. Traceable Nanoparticles with Dual-targeting and ROS-response for RNAi-based Immunochemotherapy of Intracranial Glioblastoma Treatment. Advanced Materials, 2018,30: 1705054. (IF=32.09)PDF

2.   Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164−4171. (IF=16.28)PDF

3.  Zhiguo Lu, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Lei Chen, Xin Zhang*. Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1578–1589. (IF=5.068)PDF

4.  Jie Shen, Zhiguo Lu, Tianlu Zhang, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Yuping Wei, Guiying Liu, Xin Zhang*. Effects of Wallpaper with the Ability of Photo-Activated Releasing Fragrance on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1556–1567. (IF=5.068)PDF

5. Zhiguo Lu, Yongchang Zheng, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Xin Zhang*. Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1675–1687. (IF=5.068)PDF


1.   Zhiguo Lu1, Yan Li1, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for  Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27(46):1703967. (IF= 19.97)PDF

2.   Jingli Chen, Jun Yang, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang, Xin Zhang*. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. Theranostics, 2017, 7, 4149-4167. (IF=12.201) PDF

3.   Chenmeng Qiao, Jun Yang, Lei Chen,* Jie Weng*, Xin Zhang*.Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells. Biomaterials Science, 2017,  5, 1603–1611. (IF= 7.69)PDF

4.   Chenmeng Qiao, Jun Yang, Qi Shen, Yan-Qin Shen, JieWeng*, Xin Zhang*.RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review. Journal of Biomedical Nanotechnology, 2017, Vol. 13, 1–20. (IF= 5.068) PDF



1.    Zhang Ran1, Li Yan1, Hu Bing Bing, Lu Zhi Guo, Zhang Jin Chao*, Zhang Xin*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF=32.09)PDF

2.    Qiao Chenmeng1, Yang Jun1, Li Yan, Weng Jie*, Shao Yiming*, Zhang Xin*. Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines. Biomaterials, 2016, 85: 1-17. (IF=15.304)PDF

3.    Hu Bingbing, Zeng Mou, Chen Jingli, Zhang Zhenzhong, Zhang Xiaoning, Fan Zhanming*, Zhang Xin*. External magnetic field-induced targeted delivery of highly sensitive iron oxide nanocubes for MRI of myocardial infarction. Small, 2016, 34: 4707-4712. (IF=15.153)PDF

4.    Li Yan, Zhang Ruilong, Lu Zhiguo, Ma Guanghui, Chen Lei, Tang Qunwei*, Zhang Xin*. Microenvironment responsive three-pronged approach breaking traditional chemotherapy to target cancer stem cells for synergistic inoperable large tumor therapy. Small, 2016, 40: 5516-5523. (IF=15.153)PDF



1.    Deng Heng, Dai Fengying, Ma Guanghui, Zhang Xin*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 273645-3653. (IF= 32.09PDF

2.    Hu Bingbing, Dai Fengying, Fan Zhanming, Ma Guanghui, Tang Qunwei*, Zhang Xin*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27: 5499-5505. (IF= 32.09)PDF

3.    Li Yan1, Liu Ruiyuan1, Yang Jun, Shi Yuanjie, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14. (IF= 15.304)PDF

4.    Li Yan1, Liu Ruiyuan1, Shi Yuanjie, Zhang Zhenzhong*, Zhang Xin*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596. (IF= 8.063)PDF

5.    Yaqiong Dong1, Jun Yang1, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang*, Xin Zhang*. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors, Theranostics, 2015; 5(8): 890-904. (IF= 8.063)PDF



1.    Li Yan, Liu Ruiyuan, Yang Jun, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745. (IF= 15.304)PDF

2.    Liu Hongmei, Li Yan, Mozhi Anbu, Zhang Liang, Liu Yilan, Xu Xia, Xing Jianmin, Liang Xingjie, Ma Guanghui, Yang Jun*, Zhang Xin*. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 35: 6519-6533. (IF= 15.304)PDF

3.    Yang Jun, Liu Hongmei, Zhang Xin*. Design, Preparation and application of nucleic acid delivery carriers. Biotechnology Advances, 2014, 32: 804-817. (IF= 18.248)PDF

4.    Deng Heng, Zhong Yanqi, Du Meihong, Liu Qingjun, Fan Zhanming*, Dai Fengying*, Zhang Xin*. Theranostic self-Assembly structure of gold nanoparticles for NIR photothermal therapy and X-ray computed tomography imaging. Theranostics, 2014, 4: 904-918. (IF= 12.201)PDF

5.    Li Yan1, Cheng Qiang1, Jiang Qian, Huang Yuanyu, Liu Hongmei, Zhao Yuliang, Cao Weipeng, Ma Guanghui, Dai Fengying*, Liang Xingjie*, Liang Zicai*, Zhang Xin*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114. (IF= 11.467)PDF

6.    Liu Hongmei, Qiao Chenmeng, Yang Jun, Weng Jie*, Zhang Xin*. Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo. Journal of Materials Chemistry B, 2014, 2: 5910-5924. (IF=4.776)PDF

7.    Zhong Yanqi1, Dai Fengying1, Deng Heng, Du Meihong, Zhang Xiaoning*, Liu Qingjun*, Zhang Xin*. A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b-PAA@SPION. Journal of Materials Chemistry B, 2014, 2: 2938-2946. (IF=4.776)PDF

8.    Dai Fengying, Du Meihong, Liu Yingguo, Liu Guiying*, Liu Qingjun*, Zhang Xin*. Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis. Journal of Materials Chemistry B, 2014, 2: 2240-2247. (IF=4.776)  PDF


    Before 2013

1.    Ren Tianbin, Liu Qiuming, Lu Hang, Liu Hongmei, Zhang Xin*, Du Jianzhong*. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery. Journal of Materials Chemistry, 2012, 22: 12329-12338. (IF=6.626, 分刊前)PDF

2.    Zhang Xin, Sharma Kamal Kant, Boeglin Marcel, Ogier Joelle, Mainard Didier, Voegel Jean-Claude, Mely Yves*, Benkirane-Jessel Nadia*. Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Letters, 2008, 8: 2432-2436. (IF= 12.709)PDF

3.    Zhang Xin, Oulad-Abdelghani Mustapha, Zelkin Alexander, Wang Yajun, Haikel Youssef, Mainard Didier, Voegel Jean-Claude, Caruso Frank*, Benkirane-Jessel Nadia*. Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation. Biomaterials, 2010, 31: 1699-1706. (IF= 15.304PDF

4.    Zhang Xin, Kovtun Anna, Mendoza-Palomares Carlos, Oulad-Abdelghani Mustapha, Fioretti Florence, Rinckenbach Simon, Mainard Didier, Epple Matthias, Benkirane-Jessel Nadia*. SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. Biomaterials, 2010, 31: 6013-6018. (IF= 15.304)  PDF

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