Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering




1. Huan Peng#,Yan Li#, Weihong Ji, Ruichen Zhao, Zhiguo Lu, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Jingwen Wang, Wenli Wang, Jun Yang,  Xin Zhang*.  Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinsons Disease. ACS Nano, 2022,16,1,869-884. (IF=15.811) 

2. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Xin Zhang*.Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases. Advanced Drug Delivery Reviews, 2022, 180,114029.(IF=18.881) 

3. Ruiyuan Liu#, Jun Yang#, Xinyu Qiu, Weihong Ji, Jie Shen, Yan Li, Zhiguo Lu, Yanyue Wu, Wenli Wang, Jing Wang, Jifu  Hao, Xin Zhang, “Cascaded rocket” nanosystems with spatiotemporal separation for triple-synergistic therapy of     Alzheimer’s diseaseAdvanced Healthcare Materials, 2022, 11: 2101748. 11.092  (IF=11.092) 

4. Jie Shen, Jingwen Wang, Qiulian Hao, Weihong Ji, Huan Peng, Yanyue Wu, Ruichen Zhao, Xinyu Qiu, Wenl Wang, Jun Yang, Yan Li, Tianlu Zhang, Zhiguo Lu*, Xin Zhang*, Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs’ Spatiotemporal Behaviors. Advanced Functional Materials. 2022, 2209749. (IF=19.978) 



1.  Jie Shen, Zhiguo Lu, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 2101993. (IF= 30.85)

2. Weihong Ji, Yan Li, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, ZhiguoLu, JunYang, XinZhang*. Selfcatalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021, 202105711.  (IF= 30.85)

3. Weihong Ji, Yan Li, Ruiyuan Liu, Zhiguo Lu, Linying Liu, Zhuyan Shi, Jie Shen, Xin Zhang*. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a ‘‘nanoguard’’ for synergistic treatment of synucleinopathies. Materials Horizons, 2021, 8, 1199-1206. (IF= 13.27)


1.  Ruiyuan Liu Jun Yang Linying Liu Zhiguo Lu Zhuyan Shi Weihong Ji Jie Shen Xin Zhang* An ‘Amyloid-β  Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial DysfunctionAdvanced Science, 2020, 7, 1901555. (IF= 15.840)

2. Yan Li, Linying Liu, Weihong Ji, Huan Peng, Ruichen Zhao, Xin Zhang*. Strategies and materials of “SMART” non-viral vectors: Overcoming thebarriers for brain gene therapy. Nano Today, 2020, 35: 101006. (IF=16.907)

3. Linying Liu,Yan Li, Huan Peng, Ruiyuan Liu,Weihong Ji, Zhuyan Shi, JieShen,Guanghui Ma, Xin Zhang*.Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein 4 and immune activation of Parkinson’s disease. Science Advances, 2020, 6: eaba3967. (IF=13.116)

4. Jun Yang Zhuyan Shi Ruiyuan Liu Yanyue Wu Xin Zhang* Combined-therapeutic strategies synergistically  potentiate glioblastoma multiforme treatment via nanotechnology Theranostics, 2020, 10(7)3223-3239. (IF=8.579)

5. Zhiguo Lu, Jianze Wang, Lina Qu, Guanghan Kan,Tianlu Zhang, Jie Shen,Yan Li, Jun Yang, Yunwei Niu, Zuobing Xiao,Yinghui Li*, Xin Zhang*. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. Bioact. Mater. 2020, 5 (4), 1127-1137.  (IF=8.724)


 1.  Qi Shen, Jun Yang, Ruiyuan Liu, Linying Liu, Jinchao Zhang, Shigang Shen*, Xin Zhang*. Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy. Materials Horizons. 2019, 6, 810-816. (IF=14.356)

  2.  Linying Liu, Yan Li, Ruiyuan Liu, Qi Shen, Yanhui Li, Zhuyan Shi, Jie Shen, Weihong Ji, Xin Zhang*, Switchable  Nanoparticle for Programmed Gene-chem Delivery with Enhanced Neuronal Recovery and CT Imaging for Neurodegenerative Disease Treatment. Materials Horizons, 2019, 6, 1923-1929.  (IF=14.356)


1.   Chenmeng Qiao, Jun Yang, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*. Traceable Nanoparticles with Dual-targeting and ROS-response for RNAi-based Immunochemotherapy of Intracranial Glioblastoma Treatment. Advanced Materials, 2018,30: 1705054. (IF=27.398)PDF

2.   Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164−4171. (IF=14.695)PDF

3.  Zhiguo Lu, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Lei Chen, Xin Zhang*. Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1578–1589. (IF=5.068)PDF

4.  Jie Shen, Zhiguo Lu, Tianlu Zhang, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Yuping Wei, Guiying Liu, Xin Zhang*. Effects of Wallpaper with the Ability of Photo-Activated Releasing Fragrance on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1556–1567. (IF=5.068)PDF

5. Zhiguo Lu, Yongchang Zheng, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Xin Zhang*. Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System. J. Biomed. Nanotechnol. 2018, 14, 1675–1687. (IF=5.068)PDF


1.   Zhiguo Lu1, Yan Li1, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27(46):1703967. (IF= 15.621)PDF

2.   Jingli Chen, Jun Yang, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang, Xin Zhang*. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. Theranostics, 2017, 7, 4149-4167. (IF= 8.063) PDF

3.   Chenmeng Qiao, Jun Yang, Lei Chen,* Jie Weng*, Xin Zhang*.Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells. Biomaterials Science, 2017,  5, 1603–1611. (IF= 4.210)PDF

4.   Chenmeng Qiao, Jun Yang, Qi Shen, Yan-Qin Shen, JieWeng*, Xin Zhang*.RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review. Journal of Biomedical Nanotechnology, 2017, Vol. 13, 1–20. (IF= 5.068) PDF



1.    Zhang Ran1, Li Yan1, Hu Bing Bing, Lu Zhi Guo, Zhang Jin Chao*, Zhang Xin*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF=27.398)PDF

2.    Qiao Chenmeng1, Yang Jun1, Li Yan, Weng Jie*, Shao Yiming*, Zhang Xin*. Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines. Biomaterials, 2016, 85: 1-17. (IF=10.273)PDF

3.    Hu Bingbing, Zeng Mou, Chen Jingli, Zhang Zhenzhong, Zhang Xiaoning, Fan Zhanming*, Zhang Xin*. External magnetic field-induced targeted delivery of highly sensitive iron oxide nanocubes for MRI of myocardial infarction. Small, 2016, 34: 4707-4712. (IF=10.856)PDF

4.    Li Yan, Zhang Ruilong, Lu Zhiguo, Ma Guanghui, Chen Lei, Tang Qunwei*, Zhang Xin*. Microenvironment responsive three-pronged approach breaking traditional chemotherapy to target cancer stem cells for synergistic inoperable large tumor therapy. Small, 2016, 40: 5516-5523. (IF=10.856)PDF



1.    Deng Heng, Dai Fengying, Ma Guanghui, Zhang Xin*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 273645-3653. (IF= 27.398PDF

2.    Hu Bingbing, Dai Fengying, Fan Zhanming, Ma Guanghui, Tang Qunwei*, Zhang Xin*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27: 5499-5505. (IF= 27.398)PDF

3.    Li Yan1, Liu Ruiyuan1, Yang Jun, Shi Yuanjie, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14. (IF= 10.273)PDF

4.    Li Yan1, Liu Ruiyuan1, Shi Yuanjie, Zhang Zhenzhong*, Zhang Xin*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596. (IF= 8.063)PDF

5.    Yaqiong Dong1, Jun Yang1, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang*, Xin Zhang*. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors, Theranostics, 2015; 5(8): 890-904. (IF= 8.063)PDF



1.    Li Yan, Liu Ruiyuan, Yang Jun, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745. (IF= 10.273)PDF

2.    Liu Hongmei, Li Yan, Mozhi Anbu, Zhang Liang, Liu Yilan, Xu Xia, Xing Jianmin, Liang Xingjie, Ma Guanghui, Yang Jun*, Zhang Xin*. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 35: 6519-6533. (IF= 10.273)PDF

3.    Yang Jun, Liu Hongmei, Zhang Xin*. Design, Preparation and application of nucleic acid delivery carriers. Biotechnology Advances, 2014, 32: 804-817. (IF= 12.831)PDF

4.    Deng Heng, Zhong Yanqi, Du Meihong, Liu Qingjun, Fan Zhanming*, Dai Fengying*, Zhang Xin*. Theranostic self-Assembly structure of gold nanoparticles for NIR photothermal therapy and X-ray computed tomography imaging. Theranostics, 2014, 4: 904-918. (IF= 8.063)PDF

5.    Li Yan1, Cheng Qiang1, Jiang Qian, Huang Yuanyu, Liu Hongmei, Zhao Yuliang, Cao Weipeng, Ma Guanghui, Dai Fengying*, Liang Xingjie*, Liang Zicai*, Zhang Xin*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114. (IF= 7.877)PDF

6.    Liu Hongmei, Qiao Chenmeng, Yang Jun, Weng Jie*, Zhang Xin*. Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo. Journal of Materials Chemistry B, 2014, 2: 5910-5924. (IF=4.776)PDF

7.    Zhong Yanqi1, Dai Fengying1, Deng Heng, Du Meihong, Zhang Xiaoning*, Liu Qingjun*, Zhang Xin*. A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b-PAA@SPION. Journal of Materials Chemistry B, 2014, 2: 2938-2946. (IF=4.776)PDF

8.    Dai Fengying, Du Meihong, Liu Yingguo, Liu Guiying*, Liu Qingjun*, Zhang Xin*. Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis. Journal of Materials Chemistry B, 2014, 2: 2240-2247. (IF=4.776)  PDF


    Before 2013

1.    Ren Tianbin, Liu Qiuming, Lu Hang, Liu Hongmei, Zhang Xin*, Du Jianzhong*. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery. Journal of Materials Chemistry, 2012, 22: 12329-12338. (IF=6.626, 分刊前)PDF

2.    Zhang Xin, Sharma Kamal Kant, Boeglin Marcel, Ogier Joelle, Mainard Didier, Voegel Jean-Claude, Mely Yves*, Benkirane-Jessel Nadia*. Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Letters, 2008, 8: 2432-2436. (IF= 12.080)PDF

3.    Zhang Xin, Oulad-Abdelghani Mustapha, Zelkin Alexander, Wang Yajun, Haikel Youssef, Mainard Didier, Voegel Jean-Claude, Caruso Frank*, Benkirane-Jessel Nadia*. Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation. Biomaterials, 2010, 31: 1699-1706. (IF= 10.273PDF

4.    Zhang Xin, Kovtun Anna, Mendoza-Palomares Carlos, Oulad-Abdelghani Mustapha, Fioretti Florence, Rinckenbach Simon, Mainard Didier, Epple Matthias, Benkirane-Jessel Nadia*. SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. Biomaterials, 2010, 31: 6013-6018. (IF= 8.806)  PDF

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